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- Tumor Necrosis Factor (TNF) superfamily OX40L Binding Antibody, Mouse Monoclonal [MA352B-100 or MA352B-025]
Tumor Necrosis Factor (TNF) superfamily OX40L Binding Antibody, Mouse Monoclonal [MA352B-100 or MA352B-025]
Product Description
Tumor Necrosis Factor (TNF) superfamily OX40L Neutralizing Antibody, Mouse Monoclonal [MA352B-100 or MA352B-025]
The tumor necrosis factor (TNF) superfamily (TNFSF) of cytokines and TNF receptor superfamily (TNFRSF) display diverse physiological functions and play critical roles in the development and homeostasis of the immune-, nervous- and musculoskeletal-systems in mammals. TNFSF consists of 19 known ligands that contain the extracellular TNF homology domain (THD) and are all initially expressed as type II transmembrane proteins, although most can exist also in soluble form after extracellular domain cleavage by proteolysis. These ligands signal through 29 structurally related type I transmembrane receptor proteins of TNFRSF containing the extracellular cysteine-rich domain (CRD). Abnormal expression of TNF family cytokines or their receptors has been linked to a host of major human diseases including arthritis, psoriasis, osteoporosis and cancer. Elevated localized expression of TNFα (TNF alpha) has been shown to be one of the underlying causes for various autoimmune and inflammatory disorders such as psoriasis and arthritis. While biologic therapies blocking TNFα currently represent the largest-selling class of blockbuster drugs globally, the underlying causes of TNFα signaling in disease onset and progression as well as resistance to anti-TNFα therapy in some patients remain obscure.
GenHunter has 3 TNF superfamily monoclonal antibodies: a neutralizing mAb (NAb) and 2 binding mAbs.
TNF Superfamily Antibody Products Available:
Monoclonal Antibody Description | Clone | Isotype | Specificity | Volume | Applications |
Cat. No. |
Click to Order |
Tumor Necrosis Factor (TNF) superfamily 4-1BBL Neutralizing Antibody, Mouse Monoclonal |
9G3 | Not tested |
4-1BBL |
100µg or 25µg |
ELISA,WB |
Order | |
Tumor Necrosis Factor (TNF) superfamily 4-1BBL Binding Antibody, Mouse Monoclonal |
31H9-B4 | Not tested |
4-1BBL |
100µg or 25µg |
ELISA,WB |
Order | |
Tumor Necrosis Factor (TNF) superfamily OX40L Binding Antibody, Mouse Monoclonal | 4B3-D4 | Not tested |
OX40L |
100µg or 25µg |
ELISA,WB |
Order |
We also have many other antibody and antigen products (CLICK HERE or names below) including for:
SARS-CoV-2 (COVID-19), Human IL-24, Human IL-20R2, Nplate (Romiplostim), Human VEGF-R, Endo180 (uPARAP, CD280), Tumor Necrosis Factor (TNF) superfamily, SIRPα (Signal-regulatory protein alpha), Rabies virus, TRIMER-TAG, AP (alkaline phosphatase).
All products are FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES.
References:
Yang, X. et al (2017). Functional Detection of TNF Receptor Family Members by Affinity-Labeled Ligands. Scientific Reports. 7:694. https://www.nature.com/articles/s41598-017-06343-4Antibody Specifications | |
Antibody Name |
Tumor Necrosis Factor (TNF) superfamily OX40L Binding Antibody, Mouse Monoclonal |
Clone No. | 4B3-D4 |
Class | Mouse Monoclonal |
Catalog No / SKU | MA352B-100 (for 100 µg) or MA352B-025 (for 25 µg) |
IgG subtype | Not tested |
Specificity | OX40L |
Binding / Neutralizing mAb | Binding mAb |
Volume | 25 or 100 ug |
Provided as | Liquid |
Applications | ELISA Western Blot at 1:800 - 1:2000 |
Concentration | ~ 1 mg/mL |
Purification | Affinity purified, >99% determined by HPLC (purification as in this Nature Communications reference) |
Storage conditions | Store at -20°C long term, Avoid freeze / thaw cycle |
All products are FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES.
Documents
TNF Superfamily Antibody Products Available:
Monoclonal Antibody Description | Clone | Isotype | Specificity | Volume | Applications |
Cat. No. |
Click to Order |
Tumor Necrosis Factor (TNF) superfamily 4-1BBL Neutralizing Antibody, Mouse Monoclonal |
9G3 | Not tested |
4-1BBL |
100µg or 25µg |
ELISA,WB |
Order | |
Tumor Necrosis Factor (TNF) superfamily 4-1BBL Binding Antibody, Mouse Monoclonal |
31H9-B4 | Not tested |
4-1BBL |
100µg or 25µg |
ELISA,WB |
Order | |
Tumor Necrosis Factor (TNF) superfamily OX40L Binding Antibody, Mouse Monoclonal | 4B3-D4 | Not tested |
OX40L |
100µg or 25µg |
ELISA,WB |
Order |
We also have many other antibody and antigen products (CLICK HERE or names below) including for:
SARS-CoV-2 (COVID-19), Human IL-24, Human IL-20R2, Nplate (Romiplostim), Human VEGF-R, Endo180 (uPARAP, CD280), Tumor Necrosis Factor (TNF) superfamily, SIRPα (Signal-regulatory protein alpha), Rabies virus, TRIMER-TAG, AP (alkaline phosphatase).
All products are FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES.