Tumor Necrosis Factor (TNF) superfamily 4-1BBL Neutralizing Antibody, Mouse Monoclonal [MA351N-100 or MA351N-025] 

The tumor necrosis factor (TNF) superfamily (TNFSF) of cytokines and TNF receptor superfamily (TNFRSF) display diverse physiological functions and play critical roles in the development and homeostasis of the immune-, nervous- and musculoskeletal-systems in mammals. TNFSF consists of 19 known ligands that contain the extracellular TNF homology domain (THD) and are all initially expressed as type II transmembrane proteins, although most can exist also in soluble form after extracellular domain cleavage by proteolysis. These ligands signal through 29 structurally related type I transmembrane receptor proteins of TNFRSF containing the extracellular cysteine-rich domain (CRD). Abnormal expression of TNF family cytokines or their receptors has been linked to a host of major human diseases including arthritis, psoriasis, osteoporosis and cancer. Elevated localized expression of TNFα (TNF alpha) has been shown to be one of the underlying causes for various autoimmune and inflammatory disorders such as psoriasis and arthritis. While biologic therapies blocking TNFα currently represent the largest-selling class of blockbuster drugs globally, the underlying causes of TNFα signaling in disease onset and progression as well as resistance to anti-TNFα therapy in some patients remain obscure.

GenHunter has 3 TNF superfamily monoclonal antibodies: a neutralizing mAb (NAb) and 2 binding mAbs.

TNF Superfamily Antibody Products Available:

All products are FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES.

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