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Human VEGF-R Binding Antibody, Mouse Monoclonal [MA251B-100 or MA251B-025]

$350.00
SKU:
MA251B-100
Quantity:
Description
Specifications
Ordering
Documents

Product Description

Human VEGF-R Binding Antibody, Mouse Monoclonal [MA251B-100 or MA251B-025] 

Vascular endothelial growth factor (VEGF) signals through its receptor VEGF-R and plays a critical role during normal embryonic angiogenesis as well as in the pathological angiogenesis that occurs in a number of diseases including age related eye disease, wet AMD (advanced neovascular age-related macular degeneration), and cancer. Soluble VEGF-R-Fc (Eylea), invented by scientists at Regeneron, has been shown to be highly effective as a blocker to inhibit VEGF binding and signaling via VEGF-R. Eylea has been approved to treat age related wet AMD and cancer (References 1-2, see below).

GenHunter has 2 monoclonal antibodies against Eylea (VEGF-R-Fc): a neutralizing mAb (NAb) and a binding mAb with specificity to human VEGF-R (vascular endothelial growth factor receptor).

 

VEGF-R Antibody & Antigen Products Available:

Product Description   Clone   Isotype  Specificity          Volume   Applications

  Cat. No.                         

Click to Order

Human VEGF-R Neutralizing Antibody, Mouse Monoclonal 9F11-C7    IgG1,Kappa

Human VEGF-R

100µg
or 25µg

ELISA,WB

MA251N-100

MA251N-025

Order
Human VEGF-R Binding Antibody, Mouse Monoclonal 4D5-G10    IgG1,Kappa

Human VEGF-R

100µg
or 25µg 

ELISA,WB

MA251B-100

MA251B-025

Order
Recombinant Human VEGF-R-Fc Fusion Protein      

 

100µg
or 25µg 

 

MP204-100

MP204-025

Order

We also have many other antibody and antigen products (CLICK HERE or names below) including for:
SARS-CoV-2 (COVID-19), Human IL-24, Human IL-20R2, Nplate (Romiplostim), Human VEGF-R, Endo180 (uPARAP, CD280), Tumor Necrosis Factor (TNF) superfamily, SIRPα (Signal-regulatory protein alpha), Rabies virus, Trimer-Tag, RSV (Respiratory Syncytial Virus)HSV-2 (Herpes Simplex Virus 2), and AP (alkaline phosphatase).


References:

  1. Holash, J. et al: VEGF-Trap: a VEGF blocker with potent antitumor effects. (2002) PNAS USA. 99:11393-11398. https://www.pnas.org/doi/full/10.1073/pnas.172398299
  2. Papadopoulas, N. et al: Binding and neutralization of vascular endothelial growth factor (VEGF) and related ligands by VEGF Trap, ranibizumab and bevacizumab. (2012) Angiogenesis. 15:171-185. https://link.springer.com/article/10.1007/s10456-011-9249-6

All products are FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES.

Antibody Specifications
Antibody Name

Human VEGF-R Binding Antibody, Mouse Monoclonal

Clone No. 4D5-G10
Class Mouse Monoclonal
Catalog No / SKU MA251B-100 (for 100 µg) or MA251B-025 (for 25 µg)
IgG subtype IgG1, Kappa
Specificity Human VEGF-R
Binding / Neutralizing mAb Binding mAb
Volume 25 or 100 ug
Provided as Liquid
Applications

ELISA: antigen binding affinity EC50 = 18 - 26 ng/mL
Western Blot at 1:1000 - 1:2000

Concentration ~ 1 mg/mL
Purification G protein affinity purified, >99% determined by HPLC
Storage conditions Store at -20°C long term, Avoid freeze / thaw cycle

All products are FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES.

Documents

 

VEGF-R Antibody & Antigen Products Available:

Product Description   Clone   Isotype  Specificity          Volume   Applications

  Cat. No.                         

Click to Order

Human VEGF-R Neutralizing Antibody, Mouse Monoclonal 9F11-C7    IgG1,Kappa

Human VEGF-R

100µg
or 25µg

ELISA,WB

MA251N-100

MA251N-025

Order
Human VEGF-R Binding Antibody, Mouse Monoclonal 4D5-G10    IgG1,Kappa

Human VEGF-R

100µg
or 25µg 

ELISA,WB

MA251B-100

MA251B-025

Order
Recombinant Human VEGF-R-Fc Fusion Protein      

 

100µg
or 25µg 

 

MP204-100

MP204-025

Order

We also have many other antibody and antigen products (CLICK HERE or names below) including for:
SARS-CoV-2 (COVID-19), Human IL-24, Human IL-20R2, Nplate (Romiplostim), Human VEGF-R, Endo180 (uPARAP, CD280), Tumor Necrosis Factor (TNF) superfamily, SIRPα (Signal-regulatory protein alpha), Rabies virus, Trimer-Tag, RSV (Respiratory Syncytial Virus)HSV-2 (Herpes Simplex Virus 2), and AP (alkaline phosphatase).



All products are FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES.