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- Human VEGF-R Neutralizing Antibody, Mouse Monoclonal [MA251N-100 or MA251N-025]
Human VEGF-R Neutralizing Antibody, Mouse Monoclonal [MA251N-100 or MA251N-025]
Product Description
Human VEGF-R Neutralizing Antibody, Mouse Monoclonal [MA251N-100 or MA251N-025]
Vascular endothelial growth factor (VEGF) signals through its receptor VEGF-R and plays a critical role during normal embryonic angiogenesis as well as in the pathological angiogenesis that occurs in a number of diseases including age related eye disease, wet AMD (advanced neovascular age-related macular degeneration), and cancer. Soluble VEGF-R-Fc (Eylea), invented by scientists at Regeneron, has been shown to be highly effective as a blocker to inhibit VEGF binding and signaling via VEGF-R. Eylea has been approved to treat age related wet AMD and cancer (References 1-2, see below).
GenHunter has 2 monoclonal antibodies against Eylea (VEGF-R-Fc): a neutralizing mAb (NAb) and a binding mAb with specificity to human VEGF-R (vascular endothelial growth factor receptor).
VEGF-R Antibody & Antigen Products Available:
Product Description | Clone | Isotype | Specificity | Volume | Applications |
Cat. No. |
Click to Order |
Human VEGF-R Neutralizing Antibody, Mouse Monoclonal | 9F11-C7 | IgG1,Kappa |
Human VEGF-R |
100µg or 25µg |
NAb,ELISA,WB |
Order | |
Human VEGF-R Binding Antibody, Mouse Monoclonal | 4D5-G10 | IgG1,Kappa |
Human VEGF-R |
100µg or 25µg |
ELISA,WB |
Order | |
Recombinant Human VEGF-R-Fc Fusion Protein |
|
100µg or 25µg |
|
Order |
We also have many other antibody and antigen products (CLICK HERE or names below) including for:
SARS-CoV-2 (COVID-19), Human IL-24, Human IL-20R2, Nplate (Romiplostim), Human VEGF-R, Endo180 (uPARAP, CD280), Tumor Necrosis Factor (TNF) superfamily, SIRPα (Signal-regulatory protein alpha), Rabies virus, Trimer-Tag, RSV (Respiratory Syncytial Virus), HSV-2 (Herpes Simplex Virus 2), and AP (alkaline phosphatase).
References:
- Holash, J. et al: VEGF-Trap: a VEGF blocker with potent antitumor effects. (2002) PNAS USA. 99:11393-11398. https://www.pnas.org/doi/full/10.1073/pnas.172398299
- Papadopoulas, N. et al: Binding and neutralization of vascular endothelial growth factor (VEGF) and related ligands by VEGF Trap, ranibizumab and bevacizumab. (2012) Angiogenesis. 15:171-185. https://link.springer.com/article/10.1007/s10456-011-9249-6
All products are FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES.
Antibody Specifications | |
Antibody Name |
Human VEGF-R Neutralizing Antibody, Mouse Monoclonal |
Clone No. | 9F11-C7 |
Class | Mouse Monoclonal |
Catalog No / SKU | MA251N-100 (for 100 µg) or MA251N-025 (for 25 µg) |
IgG subtype | IgG1, Kappa |
Specificity | Human VEGF-R |
Binding / Neutralizing mAb | Neutralizing mAb (NAb) |
Volume | 25 or 100 ug |
Provided as | Liquid |
Applications |
Neutralizing antibody: EC50 = 57 ng/mL |
Concentration | ~ 1 mg/mL |
Purification | G protein affinity purified, >99% determined by HPLC |
Storage conditions | Store at -20°C long term, Avoid freeze / thaw cycle |
All products are FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES.
Documents
VEGF-R Antibody & Antigen Products Available:
Product Description | Clone | Isotype | Specificity | Volume | Applications |
Cat. No. |
Click to Order |
Human VEGF-R Neutralizing Antibody, Mouse Monoclonal | 9F11-C7 | IgG1,Kappa |
Human VEGF-R |
100µg or 25µg |
NAb,ELISA,WB |
Order | |
Human VEGF-R Binding Antibody, Mouse Monoclonal | 4D5-G10 | IgG1,Kappa |
Human VEGF-R |
100µg or 25µg |
ELISA,WB |
Order | |
Recombinant Human VEGF-R-Fc Fusion Protein |
|
100µg or 25µg |
|
Order |
We also have many other antibody and antigen products (CLICK HERE or names below) including for:
SARS-CoV-2 (COVID-19), Human IL-24, Human IL-20R2, Nplate (Romiplostim), Human VEGF-R, Endo180 (uPARAP, CD280), Tumor Necrosis Factor (TNF) superfamily, SIRPα (Signal-regulatory protein alpha), Rabies virus, Trimer-Tag, RSV (Respiratory Syncytial Virus), HSV-2 (Herpes Simplex Virus 2), and AP (alkaline phosphatase).
All products are FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES.