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SARS-CoV-2 Spike Protein Broadly Neutralizing Antibody, Mouse Monoclonal [MA101N-100 or MA101N-025]

$295.00
SKU:
MA101N-100
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Description
Specifications
Ordering
Documents

Product Description

SARS-CoV-2 Spike Protein Broadly Neutralizing Antibody, Mouse Monoclonal [MA101N-100 or MA101N-025] 
GenHunter is now offering 13 monoclonal antibodies against 
SARS-CoV-2 (WT, Beta, Delta, Omicron BA.1, Omicron BA.2, Omicron BA.2.76, Omicron BA.4, Omicron BA.5, Omicron XBB.1.5, Omicron EG.5, Omicron JN.1, and Human ACE2; more details below and in "Ordering" tab) as well as 9 different SARS-CoV-2 antigens (WT, Beta, Delta, Omicron BA.1, Omicron BA.5, Omicron XBB.1.5, Omicron EG.5.1, Omicron JN.1, & Human ACE2). 
SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2), also known as COVID-19 coronavirus or 2019-nCoV, can infect human respiratory epithelial cells by interacting with the human ACE2 receptor. The spike protein is a large type I transmembrane protein composed of two subunits, S1 and S2. S1 primarily contains a receptor-binding domain (RBD) responsible for recognizing the cell surface receptor, while S2 includes the essential elements for membrane fusion. The S protein plays a crucial role in inducing antibody and T cell responses, as well as protective immunity. The main functions of the spike protein can be summarized as follows: mediating receptor binding and membrane fusion, defining the host range and viral specificity, serving as the primary target for neutralizing antibodies, being a critical target for vaccine design, and enabling transmission between different hosts through genetic recombination or mutations in the receptor-binding domain (RBD). References listed below.


SARS-CoV-2 Antibody & Antigen Products Available:

COVID Monoclonal Antibody Description     Clone     Isotype   Specificity                      Volume   Applications

  Cat. No.                         

Click to Order

SARS-CoV-2 Spike Protein Broadly Neutralizing Antibody, Mouse Monoclonal 5F5 IgG1,Kappa

WT, Beta, Delta,   

Omicron BA.1,

Omicron BA.2,

Omicron BA.4/5,

Omicron BA.2.76

100µg
or 25µg

NAb,ELISA,
WB

MA101N-100

MA101N-025

Order
SARS-CoV-2 Spike Protein Broadly Binding Antibody, Mouse Monoclonal 1A3 IgG1,Kappa

WT, Beta, Delta,   

Omicron BA.1,

Omicron BA.2,

Omicron BA.4/5,

XBB.1.5, EG.5, JN.1

100µg
or 25µg 

ELISA,WB

MA101B-100

MA101B-025

Order

SARS-CoV-2 Spike Protein Neutralizing Antibody

(WT and Beta), Mouse Monoclonal

6B1 IgG1,Kappa Wild type, Beta 100µg
or 25µg 
NAb,ELISA,
WB

MA102N-100

MA102N-025

Order

SARS-CoV-2 Spike Protein Neutralizing Antibody

(Beta), Mouse Monoclonal

6A9-G7   IgG1,Kappa Beta 100µg
or 25µg 
NAb,ELISA,
WB

MA103N-100

MA103N-025 

Order

SARS-CoV-2 Spike Protein Neutralizing Antibody

(Delta), Mouse Monoclonal

12C10 IgG1,Kappa Delta 100µg
or 25µg 

NAb,ELISA,
WB

MA104N-100

MA104N-025 

Order

SARS-CoV-2 Spike Protein Neutralizing Antibody

(Omicron BA.1 / BA.2), Mouse Monoclonal

3F6 Not tested Omicron BA.1/BA.2 100µg
or 25µg 

NAb,ELISA,
WB

MA105N-100

MA105N-025  

Order

SARS-CoV-2 Spike Protein Binding Antibody

(Omicron BA.1), Mouse Monoclonal

2C7-E2 Not tested Omicron BA.1 100µg
or 25µg 

ELISA,WB

MA105B-100

MA105B-025 

Order

SARS-CoV-2 Spike Protein Neutralizing Antibody

(Omicron BA.2 / BA.4/5), Mouse Monoclonal

38D2-H7  Not tested Omicron BA.2, BA.4/5    100µg
or 25µg 
NAb,ELISA,
WB

MA106N-100

MA106N-025 

Order

SARS-CoV-2 Spike Protein Neutralizing Antibody

(Omicron XBB / EG.5), Mouse Monoclonal

2B6-B7 Not tested Omicron XBB.1.5, EG.5 100µg
or 25µg 

NAb,ELISA,
WB

MA107N-100

MA107N-025 

Order

SARS-CoV-2 Spike Protein Binding Antibody

(Omicron JN.1), Mouse Monoclonal

19F1-C9 Not tested Omicron JN.1 100µg
or 25µg 

ELISA,
WB

MA108B-100

MA108B-025 

Order

 

             

SARS-CoV-2 S2 Protein (Pre-fusion) Binding Antibody, Mouse Monoclonal

5A2 IgG2b, Kappa S2 100µg
or 25µg 
ELISA,WB

MA151B-100

MA151B-025 

Order 

SARS-CoV-2 S2 Protein (Post-fusion) Binding Antibody, Mouse Monoclonal

18F8 Not tested  S2 100µg
or 25µg 

ELISA,WB

MA152B-100

MA152B-025 

Order
               

Human ACE2 Ecto domain Binding Antibody, Mouse Monoclonal

26G1-C3-G10 IgG1,Kappa

Human ACE2

Ecto domain

100µg
or 25µg 
ELISA,WB

MA161B-100

MA161B-025 

Order
COVID Antigen/Protein Products              

Recombinant SARS-CoV-2 S-Trimer Fusion Protein

(WT)

      100µg
or 25µg
 

MP101-100

MP101-025 

Order

Recombinant SARS-CoV-2 S-Trimer Fusion Protein (Beta)

      100µg
or 25µg 
 

MP102-100

MP102-025 

Order

Recombinant SARS-CoV-2 S-Trimer Fusion Protein (Delta)

      100µg
or 25µg 
 

MP103-100

MP103-025 

Order

Recombinant SARS-CoV-2 S-Trimer Fusion Protein (Omicron BA.1)

      100µg
or 25µg 
 

MP104-100

MP104-025 

Order

Recombinant SARS-CoV-2 S-Trimer Fusion Protein (Omicron BA.5)

      100µg
or 25µg 
 

MP105-100

MP105-025 

Order

Recombinant SARS-CoV-2 S-Trimer Fusion Protein (Omicron XBB.1.5)

      100µg
or 25µg 
 

MP106-100

MP106-025 

Order

Recombinant SARS-CoV-2 S-Trimer Fusion Protein (Omicron EG.5.1)

      100µg
or 25µg 
 

MP107-100

MP107-025 

Order

Recombinant SARS-CoV-2 S-Trimer Fusion Protein (Omicron JN.1)

      100µg
or 25µg 
 

MP108-100

MP108-025 

Order

Recombinant Human ACE2-Fc Fusion Protein

      100µg
or 25µg 
 

MP201-100

MP201-025 

Order

We also have many other antibody and antigen products (CLICK HERE or names below) including for:
SARS-CoV-2 (COVID-19), Human IL-24, Human IL-20R2, Nplate (Romiplostim), Human VEGF-R, Endo180 (uPARAP, CD280), Tumor Necrosis Factor (TNF) superfamily, SIRPα (Signal-regulatory protein alpha), Rabies virus, TRIMER-TAG, RSV (Respiratory Syncytial Virus)HSV-2 (Herpes Simplex Virus 2)AP (alkaline phosphatase).


All products are FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES.

 

References:

  1. Liang, J.G. et al (2021, February). S-Trimer, a COVID-19 subunit vaccine candidate, induces protective immunity in nonhuman primates. Nature Communications. 12:1346, 1-12. https://www.nature.com/articles/s41467-021-21634-1
  2. Ma, J. et al (2021, June). Cryo-electron Microscopy Structure of S-Trimer, a Subunit Vaccine Candidate for COVID-19. Journal of Virology. 95:11, 1-14. https://journals.asm.org/doi/10.1128/jvi.00194-21
  3. Richmond, P. et al (2021, February). Safety and immunogenicity of S-Trimer (SCB-2019), a protein subunit vaccine candidate for COVID-19 in healthy adults: a phase 1, randomised, double-blind, placebo-controlled trial. The Lancet. 397, 682-694. https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(21)00241-5/fulltext
  4. Bravo, L. et al. (2022, January). Efficacy of the adjuvanted subunit protein COVID-19 vaccine, SCB-2019: a phase 2 and 3 multicentre, double-blind, randomised, placebo-controlled trial. The Lancet. 399, 461-472. https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(22)00055-1/fulltext
Antibody Specifications
Antibody Name

SARS-CoV-2 Spike Protein Broadly Neutralizing Antibody, Mouse Monoclonal

Clone No. 5F5
Class Mouse Monoclonal
Catalog No / SKU MA101N-100 (for 100 µg) or MA101N-025 (for 25 µg)
IgG subtype IgG1, Kappa
Specificity WT, Beta, Delta, Omicron BA.1, Omicron BA.2, Omicron BA.4/5, Omicron BA.2.76
Binding / Neutralizing mAb             Neutralizing mAb (NAb), EC50 =   ng/mL
Volume 25 or 100 ug
Provided as Liquid
Applications Neutralizing antibody: EC50 =   ng/mL
ELISA: antigen binding affinity EC50 =  ng/mL
Western Blot at 1:1000 - 1:2000
Concentration ~ 1 mg/mL
Purification Affinity purified, >99% determined by HPLC (purification as in this Nature Communications reference)
Storage conditions Store at -20°C long term, Avoid freeze / thaw cycle

All products are FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES.

Documents

 

SARS-CoV-2 Antibody & Antigen Products Available:

 

COVID Monoclonal Antibody Description     Clone     Isotype   Specificity                      Volume   Applications

  Cat. No.                         

Click to Order

SARS-CoV-2 Spike Protein Broadly Neutralizing Antibody, Mouse Monoclonal 5F5 IgG1,Kappa

WT, Beta, Delta,   

Omicron BA.1,

Omicron BA.2,

Omicron BA.4/5,

Omicron BA.2.76

100µg
or 25µg

NAb,ELISA,
WB

MA101N-100

MA101N-025

Order
SARS-CoV-2 Spike Protein Broadly Binding Antibody, Mouse Monoclonal 1A3 IgG1,Kappa

WT, Beta, Delta,   

Omicron BA.1,

Omicron BA.2,

Omicron BA.4/5,

XBB.1.5, EG.5, JN.1

100µg
or 25µg 

ELISA,WB

MA101B-100

MA101B-025

Order

SARS-CoV-2 Spike Protein Neutralizing Antibody

(WT and Beta), Mouse Monoclonal

6B1 IgG1,Kappa Wild type, Beta 100µg
or 25µg 
NAb,ELISA,
WB

MA102N-100

MA102N-025

Order

SARS-CoV-2 Spike Protein Neutralizing Antibody

(Beta), Mouse Monoclonal

6A9-G7   IgG1,Kappa Beta 100µg
or 25µg 
NAb,ELISA,
WB

MA103N-100

MA103N-025 

Order

SARS-CoV-2 Spike Protein Neutralizing Antibody

(Delta), Mouse Monoclonal

12C10 IgG1,Kappa Delta 100µg
or 25µg 

NAb,ELISA,
WB

MA104N-100

MA104N-025 

Order

SARS-CoV-2 Spike Protein Neutralizing Antibody

(Omicron BA.1 / BA.2), Mouse Monoclonal

3F6 Not tested Omicron BA.1/BA.2 100µg
or 25µg 

NAb,ELISA,
WB

MA105N-100

MA105N-025  

Order

SARS-CoV-2 Spike Protein Binding Antibody

(Omicron BA.1), Mouse Monoclonal

2C7-E2 Not tested Omicron BA.1 100µg
or 25µg 

ELISA,WB

MA105B-100

MA105B-025 

Order

SARS-CoV-2 Spike Protein Neutralizing Antibody

(Omicron BA.2 / BA.4/5), Mouse Monoclonal

38D2-H7  Not tested Omicron BA.2, BA.4/5    100µg
or 25µg 
NAb,ELISA,
WB

MA106N-100

MA106N-025 

Order

SARS-CoV-2 Spike Protein Neutralizing Antibody

(Omicron XBB / EG.5), Mouse Monoclonal

2B6-B7 Not tested Omicron XBB.1.5, EG.5 100µg
or 25µg 

NAb,ELISA,
WB

MA107N-100

MA107N-025 

Order

SARS-CoV-2 Spike Protein Binding Antibody

(Omicron JN.1), Mouse Monoclonal

19F1-C9 Not tested Omicron JN.1 100µg
or 25µg 

ELISA,
WB

MA108B-100

MA108B-025 

Order

 

             

SARS-CoV-2 S2 Protein (Pre-fusion) Binding Antibody, Mouse Monoclonal

5A2 IgG2b, Kappa S2 100µg
or 25µg 
ELISA,WB

MA151B-100

MA151B-025 

Order 

SARS-CoV-2 S2 Protein (Post-fusion) Binding Antibody, Mouse Monoclonal

18F8 Not tested  S2 100µg
or 25µg 

ELISA,WB

MA152B-100

MA152B-025 

Order
               

Human ACE2 Ecto domain Binding Antibody, Mouse Monoclonal

26G1-C3-G10 IgG1,Kappa

Human ACE2

Ecto domain

100µg
or 25µg 
ELISA,WB

MA161B-100

MA161B-025 

Order
COVID Antigen/Protein Products              

Recombinant SARS-CoV-2 S-Trimer Fusion Protein

(WT)

      100µg
or 25µg
 

MP101-100

MP101-025 

Order

Recombinant SARS-CoV-2 S-Trimer Fusion Protein (Beta)

      100µg
or 25µg 
 

MP102-100

MP102-025 

Order

Recombinant SARS-CoV-2 S-Trimer Fusion Protein (Delta)

      100µg
or 25µg 
 

MP103-100

MP103-025 

Order

Recombinant SARS-CoV-2 S-Trimer Fusion Protein (Omicron BA.1)

      100µg
or 25µg 
 

MP104-100

MP104-025 

Order

Recombinant SARS-CoV-2 S-Trimer Fusion Protein (Omicron BA.5)

      100µg
or 25µg 
 

MP105-100

MP105-025 

Order

Recombinant SARS-CoV-2 S-Trimer Fusion Protein (Omicron XBB.1.5)

      100µg
or 25µg 
 

MP106-100

MP106-025 

Order

Recombinant SARS-CoV-2 S-Trimer Fusion Protein (Omicron EG.5.1)

      100µg
or 25µg 
 

MP107-100

MP107-025 

Order

Recombinant SARS-CoV-2 S-Trimer Fusion Protein (Omicron JN.1)

      100µg
or 25µg 
 

MP108-100

MP108-025 

Order

Recombinant Human ACE2-Fc Fusion Protein

      100µg
or 25µg 
 

MP201-100

MP201-025 

Order

We also have many other antibody and antigen products (CLICK HERE or names below) including for:
SARS-CoV-2 (COVID-19), Human IL-24, Human IL-20R2, Nplate (Romiplostim), Human VEGF-R, Endo180 (uPARAP, CD280), Tumor Necrosis Factor (TNF) superfamily, SIRPα (Signal-regulatory protein alpha), Rabies virus, TRIMER-TAG, RSV (Respiratory Syncytial Virus)HSV-2 (Herpes Simplex Virus 2)AP (alkaline phosphatase).


All products are FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES.