- Home
- Immunology
- COVID antibodies/antigens
- SARS-CoV-2 Spike Protein Broadly Neutralizing Antibody, Mouse Monoclonal [MA101N-100 or MA101N-025]
SARS-CoV-2 Spike Protein Broadly Neutralizing Antibody, Mouse Monoclonal [MA101N-100 or MA101N-025]
Product Description
SARS-CoV-2 Spike Protein Broadly Neutralizing Antibody, Mouse Monoclonal [MA101N-100 or MA101N-025]
GenHunter is now offering 13 monoclonal antibodies against SARS-CoV-2 (Hu-1/WT, Beta, Delta, Omicron BA.1, Omicron BA.2, Omicron BA.2.76, Omicron BA.4, Omicron BA.5, Omicron XBB.1.5, Omicron EG.5, Omicron JN.1, and Human ACE2; more details below and in "Ordering" tab), 9 different SARS-CoV-2 antigens (Hu-1/WT, Beta, Delta, Omicron BA.1, Omicron BA.5, Omicron XBB.1.5, Omicron EG.5.1, Omicron JN.1, & Human ACE2), and 2 COVID-19 Neutralizing Antibody Rapid Test Kits (for the Omicron JN.1 or Omicron XBB.1.5 variants).
SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2), also known as COVID-19 coronavirus or 2019-nCoV, can infect human respiratory epithelial cells by interacting with the human ACE2 receptor. The spike protein is a large type I transmembrane protein composed of two subunits, S1 and S2. S1 primarily contains a receptor-binding domain (RBD) responsible for recognizing the cell surface receptor, while S2 includes the essential elements for membrane fusion. The S protein plays a crucial role in inducing antibody and T cell responses, as well as protective immunity. The main functions of the spike protein can be summarized as follows: mediating receptor binding and membrane fusion, defining the host range and viral specificity, serving as the primary target for neutralizing antibodies, being a critical target for vaccine design, and enabling transmission between different hosts through genetic recombination or mutations in the receptor-binding domain (RBD). References listed below.
SARS-CoV-2 Antibody & Antigen Products Available:
COVID Monoclonal Antibody Description | Clone | Isotype | Specificity | Volume | Applications |
Cat. No. |
Click to Order |
SARS-CoV-2 Spike Protein Broadly Neutralizing Antibody, Mouse Monoclonal | 5F5 | IgG1,Kappa |
Hu-1/WT, Beta, Delta, Omicron BA.1, Omicron BA.2, Omicron BA.4/5, Omicron BA.2.76 |
100µg or 25µg |
NAb,ELISA, |
Order | |
SARS-CoV-2 Spike Protein Broadly Binding Antibody, Mouse Monoclonal | 1A3 | IgG1,Kappa |
Hu-1/WT, Beta, Delta, Omicron BA.1, Omicron BA.2, Omicron BA.4/5, XBB.1.5, EG.5, JN.1 |
100µg or 25µg |
ELISA,WB |
Order | |
6B1 | IgG1,Kappa | Hu-1/WT, Beta | 100µg or 25µg |
NAb,ELISA, WB |
Order | ||
6A9-G7 | IgG1,Kappa | Beta | 100µg or 25µg |
NAb,ELISA, WB |
Order | ||
12C10 | IgG1,Kappa | Delta | 100µg or 25µg |
NAb,ELISA, |
Order | ||
3F6 | Not tested | Omicron BA.1/BA.2 | 100µg or 25µg |
NAb,ELISA, |
Order | ||
2C7-E2 | Not tested | Omicron BA.1 | 100µg or 25µg |
ELISA,WB |
Order | ||
38D2-H7 | Not tested | Omicron BA.2, BA.4/5 | 100µg or 25µg |
NAb,ELISA, WB |
Order | ||
2B6-B7 | Not tested | Omicron XBB.1.5, EG.5 | 100µg or 25µg |
NAb,ELISA, |
Order | ||
19F1-C9 | Not tested | Omicron JN.1 | 100µg or 25µg |
ELISA, |
Order | ||
|
|||||||
SARS-CoV-2 S2 Protein (Pre-fusion) Binding Antibody, Mouse Monoclonal |
5A2 | IgG2b, Kappa | S2 | 100µg or 25µg |
ELISA,WB | Order | |
SARS-CoV-2 S2 Protein (Post-fusion) Binding Antibody, Mouse Monoclonal |
18F8 | Not tested | S2 | 100µg or 25µg |
ELISA,WB |
Order | |
26G1-C3-G10 | IgG1,Kappa |
Human ACE2 Ecto domain |
100µg or 25µg |
ELISA,WB | Order | ||
COVID Antigen/Protein Products | |||||||
100µg or 25µg |
Order | ||||||
100µg or 25µg |
Order | ||||||
100µg or 25µg |
Order | ||||||
Recombinant SARS-CoV-2 S-Trimer Fusion Protein (Omicron BA.1) |
100µg or 25µg |
Order | |||||
Recombinant SARS-CoV-2 S-Trimer Fusion Protein (Omicron BA.5) |
100µg or 25µg |
Order | |||||
Recombinant SARS-CoV-2 S-Trimer Fusion Protein (Omicron XBB.1.5) |
100µg or 25µg |
Order | |||||
Recombinant SARS-CoV-2 S-Trimer Fusion Protein (Omicron EG.5.1) |
100µg or 25µg |
Order | |||||
Recombinant SARS-CoV-2 S-Trimer Fusion Protein (Omicron JN.1) |
100µg or 25µg |
Order | |||||
100µg or 25µg |
Order | ||||||
COVID-19 Neutralizing Antibody Rapid Test Kits | |||||||
COVID-19 Neutralizing Antibody Rapid Test Kit (Omicron JN.1 variant) |
Omicron JN.1 |
2 or 5 tests |
NAb |
Order | |||
COVID-19 Neutralizing Antibody Rapid Test Kit (Omicron XBB.1.5 variant) |
Omicron XBB.1.5 |
2 or 5 tests |
NAb |
Order |
We also have many other antibody and antigen products (CLICK HERE or names below) including for:
SARS-CoV-2 (COVID-19), Human IL-24, Human IL-20R2, Nplate (Romiplostim), Human VEGF-R, Endo180 (uPARAP, CD280), Tumor Necrosis Factor (TNF) superfamily, SIRPα (Signal-regulatory protein alpha), Rabies virus, TRIMER-TAG, RSV (Respiratory Syncytial Virus), HSV-2 (Herpes Simplex Virus 2), AP (alkaline phosphatase).
References:
- Liang, J.G. et al (2021, February). S-Trimer, a COVID-19 subunit vaccine candidate, induces protective immunity in nonhuman primates. Nature Communications. 12:1346, 1-12. https://www.nature.com/articles/s41467-021-21634-1
- Ma, J. et al (2021, June). Cryo-electron Microscopy Structure of S-Trimer, a Subunit Vaccine Candidate for COVID-19. Journal of Virology. 95:11, 1-14. https://journals.asm.org/doi/10.1128/jvi.00194-21
- Richmond, P. et al (2021, February). Safety and immunogenicity of S-Trimer (SCB-2019), a protein subunit vaccine candidate for COVID-19 in healthy adults: a phase 1, randomised, double-blind, placebo-controlled trial. The Lancet. 397, 682-694. https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(21)00241-5/fulltext
- Bravo, L. et al. (2022, January). Efficacy of the adjuvanted subunit protein COVID-19 vaccine, SCB-2019: a phase 2 and 3 multicentre, double-blind, randomised, placebo-controlled trial. The Lancet. 399, 461-472. https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(22)00055-1/fulltext
All products are FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES.
Antibody Specifications | |
Antibody Name |
SARS-CoV-2 Spike Protein Broadly Neutralizing Antibody, Mouse Monoclonal |
Clone No. | 5F5 |
Class | Mouse Monoclonal |
Catalog No / SKU | MA101N-100 (for 100 µg) or MA101N-025 (for 25 µg) |
IgG subtype | IgG1, Kappa |
Specificity | Hu-1/WT, Beta, Delta, Omicron BA.1, Omicron BA.2, Omicron BA.4/5, Omicron BA.2.76 |
Binding / Neutralizing mAb | Neutralizing mAb (NAb) |
Volume | 25 or 100 ug |
Provided as | Liquid |
Applications | Neutralizing antibody: EC50 = Different for each variant; see ELISA image. ELISA: antigen binding affinity EC50 = Different for each variant; see ELISA image. Western Blot at 1:1000 - 1:2000 |
Concentration | ~ 1 mg/mL |
Purification | G protein affinity purified, >99% determined by HPLC (purification as in this Nature Communications reference) |
Storage conditions | Store at -20°C long term, Avoid freeze / thaw cycle |
All products are FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES.
Documents
SARS-CoV-2 Antibody & Antigen Products Available:
COVID Monoclonal Antibody Description | Clone | Isotype | Specificity | Volume | Applications |
Cat. No. |
Click to Order |
SARS-CoV-2 Spike Protein Broadly Neutralizing Antibody, Mouse Monoclonal | 5F5 | IgG1,Kappa |
Hu-1/WT, Beta, Delta, Omicron BA.1, Omicron BA.2, Omicron BA.4/5, Omicron BA.2.76 |
100µg or 25µg |
NAb,ELISA, |
Order | |
SARS-CoV-2 Spike Protein Broadly Binding Antibody, Mouse Monoclonal | 1A3 | IgG1,Kappa |
Hu-1/WT, Beta, Delta, Omicron BA.1, Omicron BA.2, Omicron BA.4/5, XBB.1.5, EG.5, JN.1 |
100µg or 25µg |
ELISA,WB |
Order | |
6B1 | IgG1,Kappa | Hu-1/WT, Beta | 100µg or 25µg |
NAb,ELISA, WB |
Order | ||
6A9-G7 | IgG1,Kappa | Beta | 100µg or 25µg |
NAb,ELISA, WB |
Order | ||
12C10 | IgG1,Kappa | Delta | 100µg or 25µg |
NAb,ELISA, |
Order | ||
3F6 | Not tested | Omicron BA.1/BA.2 | 100µg or 25µg |
NAb,ELISA, |
Order | ||
2C7-E2 | Not tested | Omicron BA.1 | 100µg or 25µg |
ELISA,WB |
Order | ||
38D2-H7 | Not tested | Omicron BA.2, BA.4/5 | 100µg or 25µg |
NAb,ELISA, WB |
Order | ||
2B6-B7 | Not tested | Omicron XBB.1.5, EG.5 | 100µg or 25µg |
NAb,ELISA, |
Order | ||
19F1-C9 | Not tested | Omicron JN.1 | 100µg or 25µg |
ELISA, |
Order | ||
|
|||||||
SARS-CoV-2 S2 Protein (Pre-fusion) Binding Antibody, Mouse Monoclonal |
5A2 | IgG2b, Kappa | S2 | 100µg or 25µg |
ELISA,WB | Order | |
SARS-CoV-2 S2 Protein (Post-fusion) Binding Antibody, Mouse Monoclonal |
18F8 | Not tested | S2 | 100µg or 25µg |
ELISA,WB |
Order | |
26G1-C3-G10 | IgG1,Kappa |
Human ACE2 Ecto domain |
100µg or 25µg |
ELISA,WB | Order | ||
COVID Antigen/Protein Products | |||||||
100µg or 25µg |
Order | ||||||
100µg or 25µg |
Order | ||||||
100µg or 25µg |
Order | ||||||
Recombinant SARS-CoV-2 S-Trimer Fusion Protein (Omicron BA.1) |
100µg or 25µg |
Order | |||||
Recombinant SARS-CoV-2 S-Trimer Fusion Protein (Omicron BA.5) |
100µg or 25µg |
Order | |||||
Recombinant SARS-CoV-2 S-Trimer Fusion Protein (Omicron XBB.1.5) |
100µg or 25µg |
Order | |||||
Recombinant SARS-CoV-2 S-Trimer Fusion Protein (Omicron EG.5.1) |
100µg or 25µg |
Order | |||||
Recombinant SARS-CoV-2 S-Trimer Fusion Protein (Omicron JN.1) |
100µg or 25µg |
Order | |||||
100µg or 25µg |
Order | ||||||
COVID-19 Neutralizing Antibody Rapid Test Kits | |||||||
COVID-19 Neutralizing Antibody Rapid Test Kit (Omicron JN.1 variant) |
Omicron JN.1 |
2 or 5 tests |
NAb |
Order | |||
COVID-19 Neutralizing Antibody Rapid Test Kit (Omicron XBB.1.5 variant) |
Omicron XBB.1.5 |
2 or 5 tests |
NAb |
Order |
We also have many other antibody and antigen products (CLICK HERE or names below) including for:
SARS-CoV-2 (COVID-19), Human IL-24, Human IL-20R2, Nplate (Romiplostim), Human VEGF-R, Endo180 (uPARAP, CD280), Tumor Necrosis Factor (TNF) superfamily, SIRPα (Signal-regulatory protein alpha), Rabies virus, TRIMER-TAG, RSV (Respiratory Syncytial Virus), HSV-2 (Herpes Simplex Virus 2), AP (alkaline phosphatase).
All products are FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES.