GenHunter is now offering 12 monoclonal antibodies against SARS-CoV-2 (WT, Beta, Delta, Omicron BA.1, Omicron BA.2, Omicron BA.2.76, Omicron BA.4, Omicron BA.5, Omicron XBB.1.5, Omicron EG.5, Omicron JN.1, and Human ACE2; more details below and in "Ordering" tab) as well as 8 different SARS-CoV-2 antigens (WT, Beta, Delta, Omicron BA.1, Omicron BA.5, Omicron XBB.1.5, Omicron JN.1, & Human ACE2). SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2), also known as COVID-19 coronavirus or 2019-nCoV, can infect human respiratory epithelial cells by interacting with the human ACE2 receptor. The spike protein is a large type I transmembrane protein composed of two subunits, S1 and S2. S1 primarily contains a receptor-binding domain (RBD) responsible for recognizing the cell surface receptor, while S2 includes the essential elements for membrane fusion. The S protein plays a crucial role in inducing antibody and T cell responses, as well as protective immunity. The main functions of the spike protein can be summarized as follows: mediating receptor binding and membrane fusion, defining the host range and viral specificity, serving as the primary target for neutralizing antibodies, being a critical target for vaccine design, and enabling transmission between different hosts through genetic recombination or mutations in the receptor-binding domain (RBD). References listed below.

SARS-CoV-2 Antibody & Antigen Products Available:

COVID Monoclonal Antibody Description	Clone	Isotype	Specificity	Volume	Applications	Cat. No.	Click to Order
SARS-CoV-2 Spike Protein Broadly Neutralizing Antibody, Mouse Monoclonal	5F5	IgG1，Kappa	WT, Beta, Delta,    Omicron BA.1, Omicron BA.2, Omicron BA.4/5, Omicron BA.2.76	100µg or 25µg	ELISA,WB	MA101N-100 MA101N-025	Order
SARS-CoV-2 Spike Protein Broadly Binding Antibody, Mouse Monoclonal	1A3	IgG1，Kappa	WT, Beta, Delta,    Omicron BA.1, Omicron BA.2, Omicron BA.4/5, XBB.1.5, EG.5, JN.1	100µg or 25µg	ELISA,WB	MA101B-100 MA101B-025	Order
SARS-CoV-2 Spike Protein Neutralizing Antibody (WT and Beta), Mouse Monoclonal	6B1	IgG1，Kappa	Wild type, Beta	100µg or 25µg	ELISA,WB	MA102N-100 MA102N-025	Order
SARS-CoV-2 Spike Protein Neutralizing Antibody (Beta), Mouse Monoclonal	6A9-G7	IgG1，Kappa	Beta	100µg or 25µg	ELISA,WB	MA103N-100 MA103N-025	Order
SARS-CoV-2 Spike Protein Neutralizing Antibody (Delta), Mouse Monoclonal	12C10	IgG1，Kappa	Delta	100µg or 25µg	ELISA,WB	MA104N-100 MA104N-025	Order
SARS-CoV-2 Spike Protein Neutralizing Antibody (Omicron BA.1 / BA.2), Mouse Monoclonal	3F6	Not tested	Omicron BA.1/BA.2	100µg or 25µg	ELISA,WB	MA105N-100 MA105N-025	Order
SARS-CoV-2 Spike Protein Binding Antibody (Omicron BA.1), Mouse Monoclonal	2C7-E2	Not tested	Omicron BA.1	100µg or 25µg	ELISA,WB	MA105B-100 MA105B-025	Order
SARS-CoV-2 Spike Protein Neutralizing Antibody (Omicron BA.2 / BA.4/5), Mouse Monoclonal	38D2-H7	Not tested	Omicron BA.2, BA.4/5	100µg or 25µg	ELISA	MA106N-100 MA106N-025	Order
SARS-CoV-2 Spike Protein Neutralizing Antibody (Omicron XBB / EG.5), Mouse Monoclonal	2B6-B7	Not tested	Omicron XBB.1.5, EG.5	100µg or 25µg	ELISA,WB	MA107N-100 MA107N-025	Order
SARS-CoV-2 S2 Protein (Pre-fusion) Binding Antibody, Mouse Monoclonal	5A2	IgG2b, Kappa	S2	100µg or 25µg	ELISA,WB	MA151B-100 MA151B-025	Order
SARS-CoV-2 S2 Protein (Post-fusion) Binding Antibody, Mouse Monoclonal	18F8	Not tested	S2	100µg or 25µg	ELISA,WB	MA152B-100 MA152B-025	Order
Human ACE2 Ecto domain Binding Antibody, Mouse Monoclonal	26G1-C3-G10	IgG1，Kappa	Human ACE2 Ecto domain	100µg or 25µg	ELISA,WB	MA161B-100 MA161B-025	Order
COVID Antigen/Protein Products
Recombinant SARS-CoV-2 S-Trimer Fusion Protein (WT)				100µg or 25µg		MP101-100 MP101-025	Order
Recombinant SARS-CoV-2 S-Trimer Fusion Protein (Beta)				100µg or 25µg		MP102-100 MP102-025	Order
Recombinant SARS-CoV-2 S-Trimer Fusion Protein (Delta)				100µg or 25µg		MP103-100 MP103-025	Order
Recombinant SARS-CoV-2 S-Trimer Fusion Protein (Omicron BA.1)				100µg or 25µg		MP104-100 MP104-025	Order
Recombinant SARS-CoV-2 S-Trimer Fusion Protein (Omicron BA.5)				100µg or 25µg		MP105-100 MP105-025	Order
Recombinant SARS-CoV-2 S-Trimer Fusion Protein (Omicron XBB.1.5)				100µg or 25µg		MP106-100 MP106-025	Order
Recombinant SARS-CoV-2 S-Trimer Fusion Protein (Omicron JN.1)				100µg or 25µg		MP107-100 MP107-025	Order
Recombinant Human ACE2-Fc Fusion Protein				100µg or 25µg		MP201-100 MP201-025	Order

All products are FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES.

 

References:

Liang, J.G. et al (2021, February). S-Trimer, a COVID-19 subunit vaccine candidate, induces protective immunity in nonhuman primates. Nature Communications. 12:1346, 1-12. https://www.nature.com/articles/s41467-021-21634-1

Ma, J. et al (2021, June). Cryo-electron Microscopy Structure of S-Trimer, a Subunit Vaccine Candidate for COVID-19. Journal of Virology. 95:11, 1-14. https://journals.asm.org/doi/10.1128/jvi.00194-21

Richmond, P. et al (2021, February). Safety and immunogenicity of S-Trimer (SCB-2019), a protein subunit vaccine candidate for COVID-19 in healthy adults: a phase 1, randomised, double-blind, placebo-controlled trial. The Lancet. 397, 682-694. https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(21)00241-5/fulltext

Bravo, L. et al. (2022, January). Efficacy of the adjuvanted subunit protein COVID-19 vaccine, SCB-2019: a phase 2 and 3 multicentre, double-blind, randomised, placebo-controlled trial. The Lancet. 399, 461-472. https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(22)00055-1/fulltext