COL3A1 (Human Collagen type III, alpha-1 chain) Antibody, Mouse Monoclonal [MA323B-100 or MA323B-025] 

GenHunter currently has monoclonal antibodies against Collagen Type I & III, 4 monoclonal antibodies against Endo180, & 1 against Trimer-Tag (Human CICP, Type I Collagen). See below for more info.

Collagen is the most abundant structural protein in mammals, constituting roughly 25-30% of total body protein. It acts as the major component of extracellular matrix and the primary "glue" or scaffolding providing strength, elasticity, and structural support to skin, bones, tendons, ligaments, and connective tissues.

Structure
• Triple Helix: Collagen is characterized by a unique triple-helix structure, where three polypeptide alpha-chains are tightly wound together, creating a rigid and strong configuration.
• Amino Acid Composition: It is rich in glycine, proline, and hydroxyproline, with glycine appearing every third amino acid, allowing for a tight, stable packing.
• Hierarchical Assembly: These triple-helix molecules, known as tropocollagen, assemble into fibrils that form fibers and networks.
• Types: There are at least 28 different types, with Type I being the most common, accounting for 90% of the collagen in the human body. Functions
• Structural Integrity: Provides tensile strength and structure to skin, bone, tendons, cartilage, and ligaments, ensuring they can withstand stretching.
• Tissue Repair and Growth: Essential in the extracellular matrix to support cell migration, tissue regeneration, and wound healing.
• Elasticity and Health: Maintains skin elasticity and supports joint health.
• Organ Protection: Acts as a protective covering for organs and aids in blood vessel structure.

Collagen production naturally declines with age, leading to decreased tissue strength.

Type III collagen is a vital fibrous protein and the second most abundant type of collagen in the human body. It is a key structural component of the extracellular matrix (ECM) found in soft, extensible tissues, particularly in the skin, lungs, intestines, and the walls of blood vessels. It works alongside Type I collagen to provide structural integrity, elasticity, and support for tissues that need to expand and recoil.

Structure of Type III Collagen
• Composition: It is a homotrimer, composed of three identical alpha-1(III) chains encoded by the COL3A1 gene.
• Triple Helix: These three chains wrap around each other to form a characteristic rope-like, right-handed triple helix.
• Amino Acid Sequence: The structure is characterized by a repeating (Gly-X-Y) sequence, where glycine is every third amino acid, allowing it to pack into a compact structure.
• Stability & Maturation: Unlike other fibrillar collagens, the N-terminal propeptide often remains partially attached in mature type III collagen, and it forms a stabilizing "cystine knot" at the C-terminal end.
• Fibrillar Formation: Type III collagen molecules assemble into long, thin fibrils, which then aggregate into fibers.

Functions of Type III Collagen
• Structural Support for Elastic Tissues: Provides strength and elasticity to hollow organs and tissues, including large blood vessels, the uterus, and the bowel.
• Collagen Regulation: It plays a crucial role in controlling the diameter of Type I collagen fibrils during formation.
• Wound Healing: It is one of the earliest collagens deposited at wound sites and is essential for skin repair and regeneration.
• Blood Clotting: It interacts with platelets, playing an active role in the blood clotting cascade.
• Signaling and Development: It acts as a signaling molecule during embryogenesis and supports fibroblast growth in the dermis.

Location - Type III collagen is found in:
• Skin (Dermis): Particularly during development and healing.
• Cardiovascular System: Blood vessels and vascular walls.
• Internal Organs: Lungs, liver, and intestine.

Collagen Antibody Products Available:

Monoclonal Antibody Description	Clone	Isotype	Specificity	Volume	Applications	Cat. No.	Click to Order
COL1A1 (Human Collagen type I, alpha-1 chain) Antibody, Mouse Monoclonal	16F4-D6	Not tested	COL1A1	100µg or 25µg	ELISA,WB	MA321B-100 MA321B-025	Order
COL3A1 (Human Collagen type III, alpha-1 chain) Antibody, Mouse Monoclonal	7B4-H9	Not tested	COL3A1	100µg or 25µg	ELISA,WB	MA323B-100 MA323B-025	Order

We also have many other primary antibodies, secondary antibodies, & antigen products (CLICK HERE or the names below) for:  SARS-CoV-2 (COVID-19), Human IL-24, Human IL-20R2, Nplate (Romiplostim), TPO (Thrombopoietin), Human VEGF-R, Collagen, Endo180 (uPARAP, CD280), Tumor Necrosis Factor (TNF) superfamily, SIRPα (Signal-regulatory protein alpha), Rabies virus, TRIMER-TAG, RSV (Respiratory Syncytial Virus), HSV-2 (Herpes Simplex Virus 2), VZV (Varicella Zoster Virus), Influenza (Flu-A & Flu-B), PIV (Parainfluenza virus), hMPV (human metapneumovirus), AP (alkaline phosphatase), PEDV (porcine epidemic diarrhea virus), PRRSV (porcine reproductive respiratory sydrome virus), plus Secondary Antibodies (for human, porcine, feline, & canine), & Vaccine Adjuvants.

References:

1. References coming soon

All products are FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES.