Recombinant Human Endo180-Fc Fusion Protein [MP205-100 or MP205-025] 

Endo180 (uPARAP, CD280) is a collagen binding factor and member of the mannose receptor family which also includes the mannose receptor (MR), the M-type phospho-lipase A2(PLA2R) receptor, and DEC-205. All 4 receptors contain an N-terminal cysteine-rich domain, a fibronectin type II (FNII) domain, 8 C-type-lectin domains (CTLDs; 10 in the case of DEC-205), a single transmembrane domain, and a short cytoplasmic domain. Endo180 has been shown to be a collagen receptor and functions in both collagen turnover (Reference 1, see below) and cell adhesion (2).

GenHunter has 4 monoclonal antibodies against human Endo180 (a neutralizing mAb and 3 binding mAbs), an antibody against Trimer-Tag (human CICP, Type 1 Collagen), plus a recombinant human Endo180-Fc fusion protein.

Endo180 Antibody & Antigen Products Available:

References:

1. Wienke, D. et al: Identification and characterization of the endocytic transmembrane glycoprotein Endo180 as a novel collagen receptor. (2003) Molecular Biology of the Cell. 14:3592-3604. https://www.molbiolcell.org/doi/10.1091/mbc.e02-12-0814
2. Thomas, E.K. et al: Endo180 Binds to the C-terminal Region of Type I Collagen. (2005) Journal of Biological Chemistry. 280:22596-22605. https://www.jbc.org/article/S0021-9258(20)61425-9/fulltext

All products are FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES.