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Human IL-20R2 Binding Antibody, Mouse Monoclonal [K501B-100 or K501B-025]

$350.00
SKU:
K501B-100
Quantity:
Description
Specifications
Ordering
Documents

Product Description

Interleukin-20 (IL-20) is a member of the IL-10 family of cytokines discovered by ZymoGenetics Inc (Reference 1, see below). Like IL-24, IL-20 signals through two heterodimeric receptors: IL-20R1/IL-20R2 and IL-22R1/IL-20R2 (1-2). Upon binding to its receptors, both IL-20 and IL-24 induce rapid activation of Stat-1 and Stat-3 transcription factors in the JAK-SAT signaling pathway, which appear to play a role in cell survival and proliferation (1, 3). Both IL-20 and IL-24 transgenic mice manifest similar phenotypes with neonatal lethality, epidermal hyperplasia, and abnormality in keratinocyte differentiation (1, 4). Abnormality in expression of these cytokines has been implicated in autoimmune diseases such as psoriasis and arthritis. Blockade of both IL-20 and IL-24 biological functions by soluble IL-20R2-Fc fusion protein was able to markedly inhibit the disease phenotype in animal models (3).

GenHunter is now offering 2 monoclonal antibodies against human IL-20R2 (a binding antibody and one that is a neutralizing & binding antibody) as well as Recombinant Human IL-20R2-Fc fusion protein. We also offer many products for human IL-24 (see links below): 5 monoclonal antibodies against human IL-24, 1 polyclonal antibody against human IL-24, 1 polyclonal antibody against rat IL-24, plus other controls.


IL-20R2 & IL-24 products available:

Product description Volume Applications

Cat. No.

Click to

Order

Human IL-20R2 Neutralizing Antibody 

    Mouse monoclonal, purified

25 & 100 µg

Western, ELISA

(at 1:1000-1:2000 dilution)

K501N-025
K501N-100
Order

Human IL-20R2 Binding Antibody 

    Mouse monoclonal, purified

25 & 100 µg

Western, ELISA

(at 1:400-1:1000 dilution)

K501B-025
K501B-100
Order

Recombinant Human IL-20R2-Fc Fusion Protein

25 & 100 µg

 

MP203-025
MP203-100
Order

 

 

 

   

Human IL-24 Antibody (Clone 2B5)

    Mouse monoclonal (Ascites)

100 µL

Western, ELISA

(at 1:1000-1:2000 dilution)

K101-2B5 Order

Human IL-24 Antibody (Clone 12D3)

    Mouse monoclonal (Ascites)

25 & 100 µL

Western, ELISA

(at 1:1000-1:2000 dilution)

K101-12D3-025
K101-12D3-100
Order

Human IL-24 Antibody (Clone 18F4-C1)

    Mouse monoclonal, purified

25 & 100 µg

Western, ELISA

(at 1:400-1:1000 dilution)

K101-18F4-025
K101-18F4-100
Order

Human IL-24 Antibody (Clone 22H8-G9)

    Mouse monoclonal, purified

25 & 100 µg

Western, ELISA

(at 1:400-1:1000 dilution)

K101-22H8-025
K101-22H8-100
Order

Human IL-24 Antibody (Clone 27D6-F5)

    Mouse monoclonal, purified

25 & 100 µg

Western, ELISA

(at 1:1000-1:2000 dilution)

K101-27D6-025
K101-27D6-100
Order

Human IL-24 Antibody

    Rabbit polyclonal (Antiserum)

100 µL

Western

(at 1:1000-1:2000 dilution)

K102 Order

Rat IL-24 Antibody

    Rabbit polyclonal (Antiserum)

100 µL

Western

(at 1:1000-1:2000 dilution)

K201 Order
IL-24-His (human) Western blot control 100 µL Western K301 Order
IL-24-His (rat) Western blot control 100 µL Western K302 Order

Human IL-24 conditioned media

    Serum-free, hIL-24 at ~1µg/mL

1 & 5 mL

Receptor activation

Working conc.: 50 ng/mL

K401
K402
Order

IL-20R2 references:

  1. Blumberg, H. et al: Interleukin 20: Discovery, receptor identification, and role in epidermal function. (2001) Cell. 104:9-19. https://www.cell.com/cell/fulltext/S0092-8674(01)00187-8
  2. Wang, M. et al: Interleukin-24 (MDA-7/MOB-5) signals through two heterodimeric receptors, IL-22R1/IL-20R2 and IL-20R1/IL-20R2. (2002) J. Biol. Chem. 277:7341-7347. https://www.jbc.org/article/S0021-9258(19)82292-5/pdf
  3. Liu, X. et al: A broad blockade of signaling from the IL-20 family of cytokines potently attenuates collagen-induced arthritis. (2016) J Immunol. 197:3029-3037. https://journals.aai.org/jimmunol/article/197/8/3029/105897/A-Broad-Blockade-of-Signaling-from-the-IL-20
  4. He, M. and Liang, P.: IL-24 transgenic mice: In vivo evidence of overlapping functions for IL-20, IL-22, and IL-24 in the epidermis. (2010) J. Immunol. 184: 1793-1798. https://journals.aai.org/jimmunol/article/184/4/1793/38783/IL-24-Transgenic-Mice-In-Vivo-Evidence-of
We also have many other antibody and antigen products (CLICK HERE or names below) including for:
SARS-CoV-2 (COVID-19), Human IL-24, Human IL-20R2, Nplate (Romiplostim), Human VEGF-R, Endo180 (uPARAP, CD280), Tumor Necrosis Factor (TNF) superfamily, SIRPα (Signal-regulatory protein alpha), Rabies virus, Trimer-Tag, RSV (Respiratory Syncytial Virus)HSV-2 (Herpes Simplex Virus 2), and AP (alkaline phosphatase).


All products are FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES.

Antibody Specifications
Antibody Name

Human IL-20R2 Binding Antibody, Mouse Monoclonal

Clone No. 59C12-H8
Class Mouse Monoclonal, purified
Catalog No / SKU K501B-100 (for 100 µg) or K501B-025 (for 25 µg)
Specificity Human IL-20R2
Binding / Neutralizing mAb             Binding mAb
Volume 25 or 100 ug
Provided as Liquid
Applications ELISA: antigen binding affinity EC50 = 29 ng/mL
Western Blot at 1:400 - 1:1000
Concentration ~0.4 mg/mL
Purification G protein affinity purified, >99% determined by HPLC
Storage conditions Store at -20°C long term, Avoid freeze / thaw cycle

All products are FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES.

Documents

AP-TAGbrochure-pdf.jpg

IL-20R2 & IL-24 products available:

Product description Volume Applications

Cat. No.

Click to

Order

Human IL-20R2 Neutralizing Antibody 

    Mouse monoclonal, purified

25 & 100 µg

Western, ELISA

(at 1:1000-1:2000 dilution)

K501N-025
K501N-100
Order

Human IL-20R2 Binding Antibody 

    Mouse monoclonal, purified

25 & 100 µg

Western, ELISA

(at 1:400-1:1000 dilution)

K501B-025
K501B-100
Order

Recombinant Human IL-20R2-Fc Fusion Protein

25 & 100 µg

 

MP203-025
MP203-100
Order

 

 

 

   

Human IL-24 Antibody (Clone 2B5)

    Mouse monoclonal (Ascites)

100 µL

Western, ELISA

(at 1:1000-1:2000 dilution)

K101-2B5 Order

Human IL-24 Antibody (Clone 12D3)

    Mouse monoclonal (Ascites)

25 & 100 µL

Western, ELISA

(at 1:1000-1:2000 dilution)

K101-12D3-025
K101-12D3-100
Order

Human IL-24 Antibody (Clone 18F4-C1)

    Mouse monoclonal, purified

25 & 100 µg

Western, ELISA

(at 1:400-1:1000 dilution)

K101-18F4-025
K101-18F4-100
Order

Human IL-24 Antibody (Clone 22H8-G9)

    Mouse monoclonal, purified

25 & 100 µg

Western, ELISA

(at 1:400-1:1000 dilution)

K101-22H8-025
K101-22H8-100
Order

Human IL-24 Antibody (Clone 27D6-F5)

    Mouse monoclonal, purified

25 & 100 µg

Western, ELISA

(at 1:1000-1:2000 dilution)

K101-27D6-025
K101-27D6-100
Order

Human IL-24 Antibody

    Rabbit polyclonal (Antiserum)

100 µL

Western

(at 1:1000-1:2000 dilution)

K102 Order

Rat IL-24 Antibody

    Rabbit polyclonal (Antiserum)

100 µL

Western

(at 1:1000-1:2000 dilution)

K201 Order
IL-24-His (human) Western blot control 100 µL Western K301 Order
IL-24-His (rat) Western blot control 100 µL Western K302 Order

Human IL-24 conditioned media

    Serum-free, hIL-24 at ~1µg/mL

1 & 5 mL

Receptor activation

Working conc.: 50 ng/mL

K401
K402
Order

We also have many other antibody and antigen products (CLICK HERE or names below) including for:

SARS-CoV-2 (COVID-19), Human IL-24, Human IL-20R2, Nplate (Romiplostim), Human VEGF-R, Endo180 (uPARAP, CD280), Tumor Necrosis Factor (TNF) superfamily, SIRPα (Signal-regulatory protein alpha), Rabies virus, Trimer-Tag, RSV (Respiratory Syncytial Virus)HSV-2 (Herpes Simplex Virus 2), and AP (alkaline phosphatase).


All products are FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES.