Trimerize Any Secreted Proteins
Trimerized Ligand Linked by Disulfide Bonds
Trimerized Soluble Receptor or Antibodies
GenHunter Corporation has been granted multiple patents in the U.S., Europe, Japan, & China covering the design and expression of any secreted therapeutic protein in disulfide bond-linked homo-trimeric forms.
Our technology, dubbed "TRIMER-TAG", takes advantage of the C-prodomains of collagen proteins, which are capable of efficient self-trimerization. Collagens are the most abundant and naturally occurring proteins secreted by mammals, including humans.
TRIMER-TAG is the first drug design platform that allows any secreted protein (e.g. cytokines, soluble receptors, Fab of mAbs) to be made as covalently linked homo-trimers with greatly increased avidity to their disease-causing targets such as the TNF family of cytokines (TNFRII, TRAIL, etc), SARS-CoV-2 COVID-19 coronavirus viral spike (S)-protein, HIV gp120, DR4, DR5, sCD4, and ApoAI. Constructs for all of these have already been made and are in development as biologic drugs.
Special Features of TRIMER-TAG:
- Naturally Secreted Trimer (C-Propeptide of Collagen)
- Disulfide Bond-Linked
- From Most Abundant Protein in Mammals (Collagen)
- Up to 28 types of Collagen to choose from
- Turn Any Secreted Protein into Covalently Linked Trimer
- Covered by multiple patents in the U.S., Europe, Japan, & China
See the animation video for our promising TRAIL/Apo2L-TRIMER here:
CLICK HERE to see the TRAIL/Apo2L-TRIMER video
Contact GenHunter at email@example.com for more details in accessing the TRIMER-TAG technology.
You can see more about Clover Biopharmaceuticals' work using TRIMER-TAG to produce a vaccine candidate for the new SARS-CoV-2 COVID-19 coronavirus with the viral spike (S)-protein:
More news stories from Clover Biopharmaceuticals here: