Site Information

 Loading... Please wait...

Human IL-24 Antibody, Rabbit polyclonal (Antiserum)

$376.00
SKU:
K102
Quantity:
Description
Specifications
Ordering
Documents

Product Description

Interleukin-24 (IL-24, also called Mob-5 or Mda-7) is an important cytokine that was identified by Dr. Peng Liang's research group at Vanderbilt University (see references below). His group used comprehensive Differential Display screening and identified over two dozen genes to be regulated by ras oncogene. They focused on a gene encoding a novel secreted protein now officially designated IL-24, which is expressed by activated T cells as well as other cell types transformed by ras oncogenes. Through a series of biochemical studies and especially the use of GenHunter's AP-TAG technology, Dr. Liang's group demonstrated that ras oncogenes could not only induce the expression of IL-24, but also its receptor(s) in the transformed cells. They went on to identify two heterodimeric cell surface receptors of IL-24, which when bound to the ligand, could activate JAK-SAT signaling pathways. Their work suggests that ras oncogenes may function to activate the IL-24 autocrine-loop, which could contribute to cancer cell survival and uncontrolled proliferation. Thus, the IL-24 signaling pathway may offer a potential therapeutic target for cancer treatment.

 

GenHunter is now offering 5 monoclonal antibodies against Human IL-24, 1 polyclonal antibody against Human IL-24, 1 polyclonal antibody against Rat IL-24, plus other controls. We also offer 2 monoclonal antibodies against Human IL-20R2.

 

IL-24 products available:

Product description Volume Applications

Cat. No.

Click to Order

Human IL-24 Antibody (Clone 2B5)

    Mouse monoclonal (Ascites)

100 µL

Western, ELISA

(at 1:1000-1:2000 dilution)

K101-2B5 Order

Human IL-24 Antibody (Clone 12D3)

    Mouse monoclonal (Ascites)

25 & 100 µL

Western, ELISA

(at 1:1000-1:2000 dilution)

K101-12D3-25
K101-12D3-100
Order

Human IL-24 Antibody (Clone 18F4-C1)

    Mouse monoclonal, purified

25 & 100 µg

Western, ELISA

(at 1:400-1:1000 dilution)

K101-18F4-25
K101-18F4-100
Order

Human IL-24 Antibody (Clone 22H8-G9)

    Mouse monoclonal, purified

25 & 100 µg

Western, ELISA

(at 1:400-1:1000 dilution)

K101-22H8-25
K101-22H8-100
Order

Human IL-24 Antibody (Clone 27D6-F5)

    Mouse monoclonal, purified

25 & 100 µg

Western, ELISA

(at 1:1000-1:2000 dilution)

K101-27D6-25
K101-27D6-100
Order

Human IL-24 Antibody

    Rabbit polyclonal (Antiserum)

100 µL

Western

(at 1:1000-1:2000 dilution)

K102 Order

Rat IL-24 Antibody

    Rabbit polyclonal (Antiserum)

100 µL

Western

(at 1:1000-1:2000 dilution)

K201 Order
IL-24-His (human) Western blot control 100 µL Western K301 Order
IL-24-His (rat) Western blot control 100 µL Western K302 Order

Human IL-24 conditioned media

    Serum-free, hIL-24 at ~1µg/mL

1 & 5 mL

Receptor activation

Working conc.: 50 ng/mL

K401
K402
Order

 

 

 

   

Human IL-20R2 Neutralizing Antibody 

    Mouse monoclonal, purified

25 & 100 µg

Western, ELISA

(at 1:1000-1:2000 dilution)

K501N-25
K501N-100
Order

Human IL-20R2 Binding Antibody 

    Mouse monoclonal, purified

25 & 100 µg

Western, ELISA

(at 1:400-1:1000 dilution)

K501B-25
K501B-100
Order

References:

  1. Zhang, R., Tan, Z. and Liang, P.: Identification of a novel ligand-receptor pair constitutively activated by ras oncogene. (2000) J. Biol. Chem. 275:24436-24443. https://www.jbc.org/article/S0021-9258(19)62189-7/fulltext
  2. Wang, M., Tan, Z., Zhang, R., Kotenko, S. V. and Liang, P.: Interleukin-24 (Mob-5/Mda-7) signals through two heterodimeric receptors, IL-22R1/IL-20R2 and IL-20R1/IL-20R2. (2002) J. Biol. Chem. 277:7341-7347. https://www.jbc.org/article/S0021-9258(19)82292-5/pdf
  3. He, M. and Liang, P.: IL-24 Transgenic Mice: In vivo evidence of overlapping functions for IL-20, IL-22, and IL-24 in the epidermis. (2010) J. Immunol. 1, 184: 1793-1798. https://journals.aai.org/jimmunol/article/184/4/1793/38783/IL-24-Transgenic-Mice-In-Vivo-Evidence-of
We also have many other antibody and antigen products (CLICK HERE or names below) including for:
SARS-CoV-2 (COVID-19), Human IL-24, Human IL-20R2, Nplate (Romiplostim), Human VEGF-R, Endo180 (uPARAP, CD280), Tumor Necrosis Factor (TNF) superfamily, SIRPα (Signal-regulatory protein alpha), Rabies virus, TRIMER-TAG, AP (alkaline phosphatase).


All products are FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES.

Antibody Specifications
Antibody Name

Human IL-24 Antibody, Rabbit polyclonal

Class Rabbit polyclonal (Antiserum)
Catalog No / SKU K102
Specificity Human IL-24 (Mob-5 or Mda-7)
Binding / Neutralizing             Binding antibody
Volume 100 uL
Provided as Liquid
Applications Western Blot at 1:1000 - 1:2000
Concentration Not tested
Storage conditions Store at -20°C long term, Avoid freeze / thaw cycle

All products are FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES.

Documents

AP-TAGbrochure-pdf.jpg

IL-24 products available:

Product description Volume Applications

Cat. No.

Click to Order

Human IL-24 Antibody (Clone 2B5)

    Mouse monoclonal (Ascites)

100 µL

Western, ELISA

(at 1:1000-1:2000 dilution)

K101-2B5 Order

Human IL-24 Antibody (Clone 12D3)

    Mouse monoclonal (Ascites)

25 & 100 µL

Western, ELISA

(at 1:1000-1:2000 dilution)

K101-12D3-25
K101-12D3-100
Order

Human IL-24 Antibody (Clone 18F4-C1)

    Mouse monoclonal, purified

25 & 100 µg

Western, ELISA

(at 1:400-1:1000 dilution)

K101-18F4-25
K101-18F4-100
Order

Human IL-24 Antibody (Clone 22H8-G9)

    Mouse monoclonal, purified

25 & 100 µg

Western, ELISA

(at 1:400-1:1000 dilution)

K101-22H8-25
K101-22H8-100
Order

Human IL-24 Antibody (Clone 27D6-F5)

    Mouse monoclonal, purified

25 & 100 µg

Western, ELISA

(at 1:1000-1:2000 dilution)

K101-27D6-25
K101-27D6-100
Order

Human IL-24 Antibody

    Rabbit polyclonal (Antiserum)

100 µL

Western

(at 1:1000-1:2000 dilution)

K102 Order

Rat IL-24 Antibody

    Rabbit polyclonal (Antiserum)

100 µL

Western

(at 1:1000-1:2000 dilution)

K201 Order
IL-24-His (human) Western blot control 100 µL Western K301 Order
IL-24-His (rat) Western blot control 100 µL Western K302 Order

Human IL-24 conditioned media

    Serum-free, hIL-24 at ~1µg/mL

1 & 5 mL

Receptor activation

Working conc.: 50 ng/mL

K401
K402
Order

 

 

 

   

Human IL-20R2 Neutralizing Antibody 

    Mouse monoclonal, purified

25 & 100 µg

Western, ELISA

(at 1:1000-1:2000 dilution)

K501N-25
K501N-100
Order

Human IL-20R2 Binding Antibody 

    Mouse monoclonal, purified

25 & 100 µg

Western, ELISA

(at 1:400-1:1000 dilution)

K501B-25
K501B-100
Order


We also have many other antibody and antigen products (CLICK HERE or names below) including for: 
SARS-CoV-2 (COVID-19)Human IL-24Human IL-20R2Nplate (Romiplostim)Human VEGF-REndo180 (uPARAP, CD280)Tumor Necrosis Factor (TNF) superfamilySIRPα (Signal-regulatory protein alpha)Rabies virusTRIMER-TAGAP (alkaline phosphatase).

All products are FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES.