- Home
- Immunology
- IL-24 antibody products
- Human IL-24 Antibody, Rabbit polyclonal (Antiserum)
Human IL-24 Antibody, Rabbit polyclonal (Antiserum)
Product Description
Interleukin-24 (IL-24, also called Mob-5 or Mda-7) is an important cytokine that was identified by Dr. Peng Liang's research group at Vanderbilt University (see references below). His group used comprehensive Differential Display screening and identified over two dozen genes to be regulated by ras oncogene. They focused on a gene encoding a novel secreted protein now officially designated IL-24, which is expressed by activated T cells as well as other cell types transformed by ras oncogenes. Through a series of biochemical studies and especially the use of GenHunter's AP-TAG technology, Dr. Liang's group demonstrated that ras oncogenes could not only induce the expression of IL-24, but also its receptor(s) in the transformed cells. They went on to identify two heterodimeric cell surface receptors of IL-24, which when bound to the ligand, could activate JAK-SAT signaling pathways. Their work suggests that ras oncogenes may function to activate the IL-24 autocrine-loop, which could contribute to cancer cell survival and uncontrolled proliferation. Thus, the IL-24 signaling pathway may offer a potential therapeutic target for cancer treatment.
GenHunter is now offering 5 monoclonal antibodies against Human IL-24, 1 polyclonal antibody against Human IL-24, 1 polyclonal antibody against Rat IL-24, plus other controls. We also offer 2 monoclonal antibodies against Human IL-20R2.
IL-24 products available:
Product description | Volume | Applications |
Cat. No. |
Click to Order |
Human IL-24 Antibody (Clone 2B5) Mouse monoclonal (Ascites) |
100 µL |
Western, ELISA (at 1:1000-1:2000 dilution) |
K101-2B5 | Order |
Human IL-24 Antibody (Clone 12D3) Mouse monoclonal (Ascites) |
25 & 100 µL |
Western, ELISA (at 1:1000-1:2000 dilution) |
K101-12D3-25 K101-12D3-100 |
Order |
Human IL-24 Antibody (Clone 18F4-C1) Mouse monoclonal, purified |
25 & 100 µg |
Western, ELISA (at 1:400-1:1000 dilution) |
K101-18F4-25 K101-18F4-100 |
Order |
Human IL-24 Antibody (Clone 22H8-G9) Mouse monoclonal, purified |
25 & 100 µg |
Western, ELISA (at 1:400-1:1000 dilution) |
K101-22H8-25 K101-22H8-100 |
Order |
Human IL-24 Antibody (Clone 27D6-F5) Mouse monoclonal, purified |
25 & 100 µg |
Western, ELISA (at 1:1000-1:2000 dilution) |
K101-27D6-25 K101-27D6-100 |
Order |
Rabbit polyclonal (Antiserum) |
100 µL |
Western (at 1:1000-1:2000 dilution) |
K102 | Order |
Rabbit polyclonal (Antiserum) |
100 µL |
Western (at 1:1000-1:2000 dilution) |
K201 | Order |
IL-24-His (human) Western blot control | 100 µL | Western | K301 | Order |
IL-24-His (rat) Western blot control | 100 µL | Western | K302 | Order |
Serum-free, hIL-24 at ~1µg/mL |
1 & 5 mL |
Receptor activation Working conc.: 50 ng/mL |
K401 K402 |
Order |
|
|
|||
Human IL-20R2 Neutralizing Antibody Mouse monoclonal, purified |
25 & 100 µg |
Western, ELISA (at 1:1000-1:2000 dilution) |
K501N-25 K501N-100 |
Order |
Human IL-20R2 Binding Antibody Mouse monoclonal, purified |
25 & 100 µg |
Western, ELISA (at 1:400-1:1000 dilution) |
K501B-25 K501B-100 |
Order |
References:
- Zhang, R., Tan, Z. and Liang, P.: Identification of a novel ligand-receptor pair constitutively activated by ras oncogene. (2000) J. Biol. Chem. 275:24436-24443. https://www.jbc.org/article/S0021-9258(19)62189-7/fulltext
- Wang, M., Tan, Z., Zhang, R., Kotenko, S. V. and Liang, P.: Interleukin-24 (Mob-5/Mda-7) signals through two heterodimeric receptors, IL-22R1/IL-20R2 and IL-20R1/IL-20R2. (2002) J. Biol. Chem. 277:7341-7347. https://www.jbc.org/article/S0021-9258(19)82292-5/pdf
- He, M. and Liang, P.: IL-24 Transgenic Mice: In vivo evidence of overlapping functions for IL-20, IL-22, and IL-24 in the epidermis. (2010) J. Immunol. 1, 184: 1793-1798. https://journals.aai.org/jimmunol/article/184/4/1793/38783/IL-24-Transgenic-Mice-In-Vivo-Evidence-of
SARS-CoV-2 (COVID-19), Human IL-24, Human IL-20R2, Nplate (Romiplostim), Human VEGF-R, Endo180 (uPARAP, CD280), Tumor Necrosis Factor (TNF) superfamily, SIRPα (Signal-regulatory protein alpha), Rabies virus, TRIMER-TAG, AP (alkaline phosphatase).
All products are FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES.
Antibody Specifications | |
Antibody Name |
Human IL-24 Antibody, Rabbit polyclonal |
Class | Rabbit polyclonal (Antiserum) |
Catalog No / SKU | K102 |
Specificity | Human IL-24 (Mob-5 or Mda-7) |
Binding / Neutralizing | Binding antibody |
Volume | 100 uL |
Provided as | Liquid |
Applications | Western Blot at 1:1000 - 1:2000 |
Concentration | Not tested |
Storage conditions | Store at -20°C long term, Avoid freeze / thaw cycle |
All products are FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES.
IL-24 products available:
Product description | Volume | Applications |
Cat. No. |
Click to Order |
Human IL-24 Antibody (Clone 2B5) Mouse monoclonal (Ascites) |
100 µL |
Western, ELISA (at 1:1000-1:2000 dilution) |
K101-2B5 | Order |
Human IL-24 Antibody (Clone 12D3) Mouse monoclonal (Ascites) |
25 & 100 µL |
Western, ELISA (at 1:1000-1:2000 dilution) |
K101-12D3-25 K101-12D3-100 |
Order |
Human IL-24 Antibody (Clone 18F4-C1) Mouse monoclonal, purified |
25 & 100 µg |
Western, ELISA (at 1:400-1:1000 dilution) |
K101-18F4-25 K101-18F4-100 |
Order |
Human IL-24 Antibody (Clone 22H8-G9) Mouse monoclonal, purified |
25 & 100 µg |
Western, ELISA (at 1:400-1:1000 dilution) |
K101-22H8-25 K101-22H8-100 |
Order |
Human IL-24 Antibody (Clone 27D6-F5) Mouse monoclonal, purified |
25 & 100 µg |
Western, ELISA (at 1:1000-1:2000 dilution) |
K101-27D6-25 K101-27D6-100 |
Order |
Rabbit polyclonal (Antiserum) |
100 µL |
Western (at 1:1000-1:2000 dilution) |
K102 | Order |
Rabbit polyclonal (Antiserum) |
100 µL |
Western (at 1:1000-1:2000 dilution) |
K201 | Order |
IL-24-His (human) Western blot control | 100 µL | Western | K301 | Order |
IL-24-His (rat) Western blot control | 100 µL | Western | K302 | Order |
Serum-free, hIL-24 at ~1µg/mL |
1 & 5 mL |
Receptor activation Working conc.: 50 ng/mL |
K401 K402 |
Order |
|
|
|||
Human IL-20R2 Neutralizing Antibody Mouse monoclonal, purified |
25 & 100 µg |
Western, ELISA (at 1:1000-1:2000 dilution) |
K501N-25 K501N-100 |
Order |
Human IL-20R2 Binding Antibody Mouse monoclonal, purified |
25 & 100 µg |
Western, ELISA (at 1:400-1:1000 dilution) |
K501B-25 K501B-100 |
Order |
We also have many other antibody and antigen products (CLICK HERE or names below) including for:
SARS-CoV-2 (COVID-19), Human IL-24, Human IL-20R2, Nplate (Romiplostim), Human VEGF-R, Endo180 (uPARAP, CD280), Tumor Necrosis Factor (TNF) superfamily, SIRPα (Signal-regulatory protein alpha), Rabies virus, TRIMER-TAG, AP (alkaline phosphatase).
All products are FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES.