|TRIMER-TAG: New technology for Trimerization of Secreted Proteins|
|Use for Biologic Drug Design & Production|
GenHunter Corporation has been granted 3 U.S. patents (7,268,116; 7,666,837; and 7,691,815) covering the design and expression of any secreted therapeutic protein in disulfide bond-linked homo-trimeric forms.
The new technology dubbed "TRIMER-TAG" takes advantage of the C-prodomains of collagen proteins, which are capable of efficient self-trimerization. Collagens are the most abundant and naturally occurring proteins secreted by mammals, including humans.
TRIMER-TAG is the first drug design platform that allows any secreted protein (e.g. cytokines, soluble receptors, Fab of mAbs) to be made as covalently linked homo-trimers with greatly increased avidity to their disease-causing targets such as the TNF family of cytokines (TNFRII, TRAIL, etc), HIV gp120, DR4, DR5, sCD4, and ApoAI. Constructs for all of these have already been made and are in development as biologic drugs.
Special Features of TRIMER-TAG:
- Naturally Secreted Trimer (C-Propeptide of Collagen)
- Disulfide Bond-Linked
- From Most Abundant Protein in Mammals (Collagen)
- Up to 28 types of Collagen to choose from
- Turn Any Secreted Protein into Covalently Linked Trimer
- Covered by 3 Issued U.S. Patents*...more
|PerfectFilm: Our Western Blotting Film|
|Inexpensive, High-Quality Autoradiography Film for many applications including Chemiluminescence|
Why spend several hundred dollars on film for Western blots?
GenHunter's PerfectFilm is a high-quality, especially sensitive blue autoradiography film that is ideal for most applications including Western blots using ECL substrates for HRP or AP!
Equivalent film 3 - 5X cheaper than competitors!
$54 for 100 5x7" sheets
$81 for 100 8x10" sheets
Features of our PerfectFilm:
- Standard High Contrast, Double Emulsion Blue Film
- High Sensitivity with Low Background
- Optimized for ECL (Enhanced Chemiluminescence), but ideal for many other applications (see below)
- Beautiful, Publication Quality Images
- Also works ...more
|The PerfectMembranes for Western Blots|
|Inexpensive Pre-cut Membranes (in PVDF or NC) that precisely fit our PerfectWestern Containers|
Still cutting your own Western blot membranes? |
Save time, effort, and reduce waste with The PerfectMembrane!
We now offer membranes in:
8.3 x 6 cm (Medium, for Bio-Rad mini-gel)
8.3 x 7.3 cm (Mini Square, for Invitrogen mini gel)
13.5 x 8.5 cm (XL, Bio-Rad Criterion or Invitrogen Midi)
PVDF, 0.45 um (Standard PVDF with 0.45 um pore size)
PVDF, 0.2 um (0.2 um pore size for smaller proteins)
PVDF, Fluor (Optimized for fluorescence)
Nitrocellulose (Standard NC with 0.45 um pore size)
The PerfectMembrane precisely fits inside our Medium, Mini Square, or Extra Large PerfectWestern containers with room for efficient movement. Our membrane offers convenience at an excellent price - about half the cost of other pre-cut membranes! ...more